Brain expression of Cre recombinase driven by pancreas-specific promoters
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چکیده
منابع مشابه
Gene deletion in urothelium by specific expression of Cre recombinase.
Urothelium that lines almost the entire urinary tract acts as a permeability barrier and is involved in the pathogenesis of major urinary diseases, including urothelial carcinoma, urinary tract infection, and interstitial cystitis. However, investigation of urothelial biology and diseases has been hampered by the lack of tissue-specific approaches. To address this deficiency, we sought to devel...
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Evaluation of thick ascending limb (TAL) function has been hindered by the limited ability to selectively examine the function of this nephron segment in vivo. To address this, a Cre/loxP strategy was employed whereby the Tamm-Horsfall (THP) promoter was used to drive Cre recombinase expression in transgenic mice. The THP gene was cloned from a mouse genomic library, and 3.7 kb of the mouse THP...
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BACKGROUND Podocytes play an important role in maintaining normal glomerular function. A podocyte-specific conditional knockout technology has been established by the use of transgenic mice expressing a podocyte-specific Cre recombinase to clarify the role of genes expressed in the podocytes. However, it may be difficult to examine the role of genes in certain pathologic conditions using conven...
متن کاملPodocyte-specific expression of cre recombinase in transgenic mice.
We report a transgenic mouse line that expresses Cre recombinase exclusively in podocytes. Twenty- four transgenic founders were generated in which Cre recombinase was placed under the regulation of a 2.5-kb fragment of the human NPHS2 promoter. Previously, this fragment was shown to drive beta-galactosidase (beta-gal) expression exclusively in podocytes of transgenic mice. For analysis, founde...
متن کاملMegakaryocyte-restricted expression of the Cre recombinase.
doi:10.1160/TH11-03-0150 Thromb Haemost 2011; 106: 554 Dear Sirs, In the recently published work from Adam Nowakowski et al. “Megakaryocyte gene targeting mediated by restricted expression of recombinase Cre” (Thromb Haemost 2011; 105.1) the authors present a transgenic mouse strain that allows Cre expression under the control of the alphaIIb promoter (1). Nowakowski et al. (1) suggest that thi...
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ژورنال
عنوان ژورنال: genesis
سال: 2010
ISSN: 1526-954X
DOI: 10.1002/dvg.20672